منابع مشابه
SUMO Wrestles with Recombination
DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs. On the other hand, when uncontrolled, HR can lead to genome rearrangements and needs to be tightly regulated. In recent years, several proteins in...
متن کاملFrauke Melchior: How SUMO wrestles other proteins
F rauke Melchior vividly remembers the afternoon when, as a postdoc in Larry Gerace's laboratory , she developed the fi lm from a particular experiment. It proved that her hypothesis was correct. The mysterious mobility shifts she'd observed in earlier experiments were due to a novel protein modifi cation: addition of the peptide she would name " small ubiquitin-related modifi er " (SUMO) (1). ...
متن کاملPTEN sumo-wrestles human RAD52 to mystery land
The PTEN gene was initially known as a gatekeeper tumor suppressor that inhibits the growth signaling mediated by phosphatidylinositol-3,4,5-trisphosphate. it is now recognized that PTEN also acts as a caretaker to maintain genomic stability. The precise mechanisms by which PTEN regulates genomic stability remain elusive, but several possibilities exist. it localizes to chromosome centromeres a...
متن کاملSUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors
Primary cilia serve as cellular antenna for various sensory signaling pathways. However, how the sensory receptors are properly targeted to the ciliary surface remains poorly understood. Here, we show that UBC-9, the sole E2 small ubiquitin-like modifier (SUMO)-conjugating enzyme, physically interacts with and SUMOylates the C terminus of small GTPase ARL-13, the worm orthologue of ARL13B that ...
متن کاملThe fellowship of the Z ring
S UMOylation of the small GTPase ARL-13 helps target signaling receptors into primary cilia, Li et al. reveal. Primary cilia are microtubule-based membrane protru-sions that serve as hubs for multiple signaling pathways. In C. elegans, ARL-13 promotes cilia assembly by coordinating intrafl agellar transport along ciliary microtubules, and the GTPase is also required for the correct localization...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2012
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1994iti1